Endocrine Abstracts

BackgroundDevelopment and application of novel drugs frequently fail due to adverse changes of TH-levels or thyroid histology in animal experiments. Such effects potentially arise from interference with thyroid gland function or key regulators of local thyroid hormone (TH) transport, metabolism and action. Deiodinases are key enzymes in TH in-/activation, with impact on development, cell differentiation and energy metabolism among other physiological pro...

Thyroid hormone (TH) homeostasis depends on the coordination of several key events to maintain proper local TH signaling, including iodide uptake, hormone synthesis, metabolism, and elimination. The three isoenzymes, Deiodinases (DIO1-3), are essential components of hormone metabolism. They catalyze iodide release the outer and/or inner ring of TH structure to convert between their active and inactive forms. The activity of DIOs has been identified as an important endpoint reg...